In infections caused by Streptococcus pyogenes, treatment should not be less than 10 days. Because of the difference in bioavailability of the suspension is not recommended to replace pills. If the kidney function of the dose adjusted according to the creatinine clearance in serum: with creatinine clearance 21-60 ml / min or in patients on hemodialysis, the daily dose should be reduced by 25%; when creatinine clearance of 20 ml / min or less and in patients undergoing peritoneal dialysis, the daily dose should be reduced by 2 times.
Preparation 60 mL oral suspension 100 mg / 5 ml. The testosterone cypionate injection suspension was prepared immediately before the first use. Shake bottle several times. Measured cap add 40 ml of cooled down to room temperature boiled water in two stages and shake vigorously after each addition until a homogeneous suspension. For the finished dosage suspension should use a measuring cap that should be well rinsed with water after each use.
How to prepare 100 ml of a suspension for oral administration of 100 mg / 5 ml. The suspension was prepared immediately before the first use. Shake bottle several times. Measured cap add 66 ml of cooled down to room temperature boiled water in two stages and shake vigorously after each addition until a homogeneous suspension. For the finished dosage suspension should use a measuring cap that should be well rinsed with water after each use.
Before use, the finished suspension should be well shaken.
Side effects: Allergic reactions: rash, skin redness, itching, itching in the genital area, eosinophilia, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome). From the nervous system : headache, dizziness, ringing in the ears. From the urogenital system: vaginitis. From the mochevydelitelnoy system: interstitial nephritis. From the digestive system: nausea, vomiting, stomatitis, diarrhea, abdominal pain, constipation, pseudomembranous enterocolitis, dysbiosis, cholestasis ; cholestatic jaundice. From the side of hematopoiesis: pancytopenia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bleeding. Laboratory findings: increased activity of “liver” transaminases and alkaline phosphatase, hyperbilirubinemia, increased urea nitrogen, hypercreatininemia, increased prothrombin time . Other: candidiasis, vitamin deficiencies in the development, shortness of breath.
Overdosing Symptoms: increased manifestations of the described side effects. Treatment: . Gastric lavage, symptomatic and supportive therapy Hemodialysis and peritoneal dialysis are ineffective.
Interaction with other drugs
blockers tubular secretion (including allopurinol, diuretics) delayed excretion of cefixime by the kidneys, which can lead to increased toxicity. Cefixime reduces prothrombin index, increases the effects of anticoagulants. Antacids testosterone cypionate injection containing aluminum or magnesium hydroxide, slow absorption of the drug.
Patients who had a history of allergic reaction to penicillin, may be sensitive to cephalosporin antibiotics. In the event of an allergic reaction, you must stop using the product and, if necessary, take appropriate action.
As with other antibacterial agents, prolonged use of cefixime may lead to an increase in Clostridium difficile, which manifests the development of severe diarrhea. In this case it is particularly important to consider the possibility of pseudomembranous colitis. During treatment possible false-positive direct Coombs’ test and lozhnopolozhi-tive reaction of urine for glucose, ketonuria.
granules for suspension for oral administration of 100 mg / 5 ml. To 60 ml suspension Primary: 32 g granules for the preparation of 60 ml suspension for oral administration of 100 mg / 5 ml in a bottle of dark glass with screw aluminum cap with gasket polyethylene and control of the first opening. Secondary: each vial together with instructions for use, complete with a measured cap is placed in a pile of cardboard. for 100 ml suspension Primary: on 53 g of granulate for the preparation of 100 ml of a suspension for oral administration of 100 mg / 5 ml in a bottle of dark glass with aluminum screw cap with gasket made of polyethylene and the control of the first opening. Secondary: each vial together with instructions for use, complete with testosterone cypionate injection a measured cap is placed in a pile of cardboard.
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