Testosterone cypionate results is an analgesic and antipyretic. Blocks of prostaglandin synthesis in the central nervous system by inhibiting cyclooxygenase 1 and 2 tsiklookseginazy, acting on pain centers and thermoregulation. Not showing the anti-inflammatory effect. No effect on prostaglandin synthesis in peripheral tissues causes lack of a negative effect on water-salt exchange (sodium and water retention) and the mucosa of the gastrointestinal tract.
Pharmacokinetics: Is rapidly and almost completely absorbed from the gastrointestinal tract. Associated with the plasma protein by 15%.Paracetamol penetrates the blood-brain barrier. Less than 1% of the accepted dose of paracetamol a nursing mother passes into breast milk. The therapeutically effective concentration of paracetamol in plasma obtained when administered at a dose of 10-15 mg / kg body weight. The half-life is 1-4 hours. Paracetamol is metabolized by the liver and excreted in the urine, mainly as the glucuronide conjugates of sulfonated and less than 5% is released in the urine unchanged.
It is used for quick relief of headache, including migraine pain, toothache, neuralgia, muscular and rheumatic pains, as well as algomenorrhea pain with injuries, burns; to reduce elevated temperatures for colds and flu.
- Hypersensitivity to paracetamol or any drug ingredient;
- severe liver or kidney disease;
- child (up to 3 years)
Use with caution in benign hyperbilirubinemia (including Gilbert’s syndrome), viral hepatitis, alcoholic liver disease, deficiency of glucose-6-phosphate dehydrogenase deficiency, alcoholism, pregnancy, lactation, in old age. The drug should not be taken concomitantly with other acetaminophen-containing medications.
Dosage and administration:
Adults, including the elderly and children over 12 years old
. According to 0.5-1 g, in 1-2 hours after a meal with plenty of testosterone cypionate results fluid 4-6 hours, the maximum daily dose to 4 grams per day
interval between doses should be not less than 4 hours. Do not take more than 8 tablets in 24 hours.
In patients with impaired hepatic or renal function, with Gilbert syndrome, in elderly patients the daily dose should be decreased and increased interval between doses.
The daily dose of from 3 to 6 years old (15 to 22 kg) – 1 g, 9 years (up to 30 kg) – 1.5 kg, up to 12 years (up to 40 kg) – 2 Multiplicity of destination – 4 twice a day; interval between each dose – at least 4 hours.
If symptoms persist, consult a doctor.
Do not exceed the stated dose. If you have received doses higher than recommended, seek medical advice, even if you feel well. An overdose of acetaminophen can cause liver failure.
The drug is not recommended for more than five days as an analgesic, and more than three days as an antipyretic without prescription and medical supervision. Increasing the daily dose or duration of treatment are possible only under medical supervision.
In the recommended doses, the drug is generally well tolerated. Paracetamol rarely causes side effects. Sometimes there may be an allergic reaction (skin rash, pruritus, urticaria, angioedema), erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), dizziness, nausea, epigastric pain; anemia, thrombocytopenia, agranulocytosis; insomnia. With prolonged use at high doses – more likely to dysfunction of the liver and kidneys, as well as the hematopoietic system.
From the digestive system: nausea, epigastric pain, elevated liver enzymes, gepatonekroz. From the Endocrine: hypoglycemia. If you have any unusual symptoms should see a doctor.
Symptoms of paracetamol overdose – nausea, vomiting, stomach pain, pale skin, anorexia. After a day or two defined signs of liver damage. In severe cases, it develops liver failure and coma. A specific antidote for paracetamol poisoning is N-acetylcysteine.
pale skin, anorexia, nausea, vomiting; gepatonekroz (necrosis severity is directly dependent on the degree of overdose). If you suspect an overdose, you should immediately seek medical help. The toxic effect of the drug in adults is possible after receiving more than 10-15 g of paracetamol: increased activity of “liver” transaminases, increased prothrombin time (after 12-48 hours after admission); detailed clinical picture of liver damage manifests itself in 1-6 days. Rarely hepatic dysfunction develops lightning speed and can be complicated by renal insufficiency (tubular necrosis).
The victim should be gastric lavage within the first 4 hours of poisoning, take adsorbents (activated charcoal) and seek medical advice, the introduction of donators of SH-groups and precursors of glutathione synthesis testosterone cypionate results – through methionine 8-9 h after the overdose and N-acetylcysteine - after 12 h. The need for additional therapeutic activities (further introduction of methionine / in administering N-acetyl cysteine) is determined depending on the concentration of acetaminophen in the blood, and the time elapsed after administration.
Before taking consult your doctor in case of:
- You have severe liver disease or kidney disease;
- You take drugs against nausea and vomiting (metoclopramide, domperidone), and drugs that lower cholesterol levels in the blood (cholestyramine);
- You are taking anticoagulants, and you every day for a long time is needed painkillers. Paracetamol in this case can be taken from time to time;
AVOID toxic liver damage paracetamol does not be combined with alcoholic drinks, as well as take people prone to chronic alcohol consumption.
During long-term treatment is necessary to monitor patterns of peripheral blood and functional state of the liver.
Interaction: when testosterone cypionate results taking the drug for a long time increases the effect of indirect anticoagulants (warfarin and other coumarin), which increases the risk of bleeding. Inducers of enzymes of microsomal oxidation in the liver (barbiturates, phenytoin, carbamazepine, rifampicin, AZT, phenytoin, ethanol, flumetsinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxicity with overdoses.
Prolonged use of barbiturates, reduces the effectiveness of paracetamol.